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Pellagra is a disease of nutritional deficiency caused by a lack of Vitamin B3, niacin, in the diet. It particularly ravaged the American South during the early twentieth century. The disease especially affected women and children. Doctors and scientists alike struggled to get to the root of the issue. From the start, it was noted that pellagra seemed to be a common issue in impoverished families that ate diets highly consisting of corn. While this was a known fact, many years passed before the mechanisms of the disease were fully understood and it was completely eradicated from the American public. This research sought to investigate the role of geographical identities in pellagra and the response to the disease. This was achieved through a literature review, analysis of primary source data, and visual components such as story explorer maps.