The overarching goal of the Musculoskeletal Imaging and Orthopaedic Biomechanics (MIOB) Laboratory is to improve human health and performance for those who suffer from musculoskeletal and orthopaedic conditions. Our approaches span experimental and computational methods. We use magnetic resonance imaging (MRI) to visualize disease and quantify anatomy, and we image bone motion directly with dynamic x-ray. Our computational studies combine patient-specific MR-based models with dynamic motion measurements to estimate internal tissue mechanics of orthopaedic tissues. Overall, the experimental and computational methods employed by the MIOB lab aim to improve patient health outcomes and reduce burdens imposed on the patient and our healthcare system.