{"id":2,"date":"2014-08-13T02:56:16","date_gmt":"2014-08-13T06:56:16","guid":{"rendered":"http:\/\/blog.uvm.edu\/mpespeni\/?page_id=2"},"modified":"2026-03-09T19:21:32","modified_gmt":"2026-03-09T23:21:32","slug":"publications","status":"publish","type":"page","link":"https:\/\/blog.uvm.edu\/mpespeni\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Please visit\u00a0Google scholar<\/a>\u00a0and ResearchGate<\/a> profiles for up-to-date publications.<\/span><\/p>\n

Please email mpespeni@uvm.edu for PDFs or find them on ResearchGate<\/a>.<\/p>\n

Pespeni lab mentees <\/strong>are underlined<\/u> with superscripts indicating career stage: postdoc(P)<\/sup>, graduate student(G)<\/sup>, undergraduate(U)<\/sup>, research assistant(R)<\/sup>.<\/p>\n

Preprints of papers in review!<\/strong><\/h4>\n

Petak, C.\u2020,<\/strong> Sadler, D.<\/strong>\u2020,<\/strong> Nunez, J.C.B.*, and Pespeni, M.H.*<\/strong> Inversion polymorphisms are maintained by balancing selection across the purple sea urchin genome. In review. Genome Biology & Evolution<\/em>. \u2020 equal contributions; *equal contributions. https:\/\/www.biorxiv.org\/content\/10.64898\/2026.01.20.700628v1<\/a><\/p>\n

Hall, A.E., Rege-Colt, M., <\/strong>and Pespeni, M.H.<\/strong> Developmental temperature drives distinct transcriptomic responses to acute temperatures and correlated differences in thermal tolerance. In review, Molecular Ecology<\/em>. https:\/\/doi.org\/10.1101\/2025.09.18.676804<\/a><\/p>\n

Sasaki, M., Rodger, A., Saratkar, C., Sharp, S., Cull-Host, J., Real, Y. <\/strong>and Pespeni, M.H.<\/strong> Seasonal acclimation of copepod community thermal limits. In review, Ecology.<\/em> https:\/\/ecoevorxiv.org\/repository\/view\/10224\/<\/a><\/p>\n

Journal articles published or in press:<\/strong><\/h4>\n

Longman, E.K.<\/strong>(P)<\/sup>,<\/strong> Nunez, J.C.B., Sanford, E., and Pespeni, M.H. <\/strong>Population structure and shell morphology of a coastal dogwhelk display evidence of glacial refugia. Accepted. Proceedings B. <\/em>Preprint: https:\/\/doi.org\/10.1101\/2025.07.22.664458<\/a><\/p>\n

McCracken, A.<\/strong>(G)<\/sup>,<\/strong> Nunez, J.C.B., and Pespeni, M.H. <\/strong>Early immune-microbiome disruption during initial sea star wasting outbreak in Southeast Alaska. Accepted. Proceedings B. <\/em>Preprint: https:\/\/doi.org\/10.1101\/2025.07.05.662347<\/a><\/p>\n

Petak, C.,<\/strong> Frati, L., Vroomans, R., Pespeni, M.H.,<\/strong> and Cheney, N. (2025) Across a range of variable environments the evolution of evolvability varies, while robustness and average fitness increase. Proc. Natl. Acad. Sci. U.S.A.<\/em> 122 (51) e2519469122\u00a0Press release<\/a>.<\/p>\n

deMayo, J.A., Brennan, R.S.<\/strong>, Pespeni, M.H.,<\/strong> Jaspers, C., Varpe, O., Lee, C.E., and Dam, H. (2025) Limits and costs of adaptation in the Anthropocene. Trends in Ecology & Evolution<\/em>.<\/p>\n

Brennan, R.S.<\/strong>(P)<\/sup>, deMayo, J.A., Finiguerra, M.B., Baumann, H., Dam, H.G., and Pespeni, M.H.<\/strong> (2025) Complementary genetic and epigenetic changes shape rapid adaptation to multiple global change stressors<\/a>. Proceedings of the National Academy of Sciences,<\/em>\u00a0122 (29) e2422782122<\/p>\n

Press release for paper above!<\/a><\/p>\n

Ashlock, L.<\/span>(G)<\/sup>, Darwin, C.<\/span>(U)<\/sup>, Crooker, J.<\/span>(U)<\/sup>, deMayo, J., Dam, H., and Pespeni, M.H.<\/strong>. (2024) Developmental Temperature, More than Long-Term Evolution, Defines Thermal Tolerance in an Estuarine Copepod<\/a>. Ecology and Evolution, 14(2), e10995.\u00a0<\/em><\/p>\n

Pespeni, M.H. <\/strong>and Lloyd, M.M.<\/u>(P)<\/sup> (2023) Sea stars resist wasting through an active immune and collagen systems.<\/a> Proceedings of the Royal Society, B,\u00a0<\/em>290 (2002), 20230347.<\/p>\n

deMayo, J.A., Brennan, R.S.<\/strong>(P)<\/sup>, Pespeni, M.H.,<\/strong> Finiguerra, M.B., Norton, L., Park, G., Baumann, H. and Dam, H.G. (2023) Simultaneous warming and acidification limits population fitness and reveals phenotype costs for a marine copepod<\/a>. Proceedings of the Royal Society, B<\/em>. 290<\/em>(2006), 20231033<\/p>\n

McCracken, A.R.<\/span>, Christensen, B.M., Munteanu, D., Case, B.K.M., Lloyd, M.M.(P)<\/sup><\/span>, Herbert, K.P. & Pespeni, M.H. <\/strong>(2023) Microbial dysbiosis precedes signs of Sea Star Wasting Disease in wild populations of <\/a>Pycnopodia helianthoides. Frontiers in Marine Science, <\/em>10, 1130912.<\/p>\n

Petak, C.<\/span>(G)<\/sup>, Frati, L., Brennan, R.S.<\/span>(P)<\/sup>, & Pespeni, M.H. <\/strong>(2023) Whole genome sequencing reveals regulatory and low pleiotropy variants underlie local adaptation to environmental variability in purple sea urchins. The American Naturalist. https:\/\/doi.org\/10.1086\/726013<\/a><\/em><\/p>\n

Brennan, R.S.<\/span>(P)<\/sup>, James, A.D., Dam, H.G., Finiguerra, M., Baumann, H., Buffalo, V., and Pespeni, M.H.\u00a0<\/strong>(2022) Experimental evolution reveals the synergistic genomic mechanisms of adaptation to ocean warming and acidification in a marine copepod<\/a>. Proceedings of the National Academy of Sciences<\/em>, 119, 38.<\/p>\n

Press: Popular article in The Scientist<\/a>. Press release<\/a>. Graphical abstract<\/a>. Poster presented at PEQG22<\/a>.<\/p>\n

Brennan, R.S.<\/span>(P)<\/sup>, James, A.D., Dam, H.G., Finiguerra, M., Baumann, H. and Pespeni, M.H.<\/strong> (2022) Loss of transcriptional plasticity but sustained adaptive capacity after adaptation to global change conditions in a marine copepod. <\/a>Nature Communications, 13, 1147.\u00a0<\/em><\/p>\n

Press: UVM Today<\/a>; Discover Magazine<\/a>.<\/p>\n

Shore, E.A.(G)<\/sup>,<\/u> Huber, K.<\/u>(U)<\/sup>, Garrett, A.D.<\/u>(G)<\/sup>, Pespeni, M.H.<\/strong> (2022) Four plastic additives reduce larval growth and survival in the sea urchin Strongylocentrotus<\/em> purpuratus\u00a0<\/em>urchin larvae. Marine Pollution Bulletin<\/em>, 175, 113385.<\/p>\n

Dam, H.G., deMayo, J.A., Park, G., Norton, L., He, X., Finiguerra, M.B., Baumann, H., Brennan, R.S<\/u>.(P)<\/sup>, and Pespeni, M.H.<\/strong> (2021) Rapid, but limited, zooplankton adaptation to simultaneous warming and acidification.\u00a0Nature Climate Change<\/em>, 11,\u00a0780\u2013786.<\/p>\n

Shore, E.A.<\/u>(G)<\/sup>, deMayo, J.A., and Pespeni, M.H.<\/strong> (2021) Microplastics reduce net population growth and fecal pellet sinking rates for the marine copepod, Acartia tonsa<\/em>. Environmental Pollution<\/em>, 284, 117379. Press release<\/em><\/a>.<\/p>\n

Pespeni, M.H.<\/strong> and Moczek, A.P. (2021) Signals of selection beyond bottlenecks between exotic populations of the bull-headed dung beetle, Onthophagus taurus<\/em>. Evolution & Development<\/em>, 23:2, 86-99.<\/p>\n

Garrett, A.<\/u>(G)<\/sup>, Brennan, R.S.<\/u>(P)<\/sup>, Steinhart, A.<\/u>(U)<\/sup>, Pelletier, A.<\/u>(U)<\/sup>, Pespeni, M.H.<\/strong> (2020) Unique genomic and phenotypic responses to extreme and variable pH conditions in purple urchin larvae. Integrative and Comparative Biology<\/em>, 60:2, 318-331.<\/p>\n

Palumbi, S.R, Evans, T.G., Pespeni, M.H.<\/strong>, Somero, G.N. (2019) Present and future adaptation of marine species assemblages: DNA-based insights into climate change from studies of physiology, genomics and evolution. Oceanography<\/em>, 32(3), 82-93.<\/p>\n

Brennan, R.<\/u>(<\/sup><\/u>P)<\/sup>, Garrett, A.<\/u>(G)<\/sup>, Huber, K.<\/u>(U)<\/sup>, Hargarten, H.<\/u>(R)<\/sup>, Pespeni, M.H.<\/strong> (2019) Rare genetic variation is important for survival in extreme low pH conditions. Proceedings of the Royal Society London B <\/em>DOI:<\/span>\u00a0https:\/\/doi.org\/10.1101\/422261<\/a><\/p>\n

Lloyd, M.M.<\/u>(P)<\/sup> and Pespeni, M.H.<\/strong> (2018) Microbiome shifts with onset and progression of Sea Star Wasting Disease revealed through time course sampling. Scientific Reports.<\/em><\/p>\n

Maynard, A., Bible, J.M., Pespeni, M.H.<\/strong>, Sanford, E., and Evans, T.G. (2018) Transcriptomic responses to extreme low salinity among locally adapted populations of Olympia oyster. Molecular Ecology<\/em><\/p>\n

Laruson, A.J., Coppard, S.E., Pespeni, M.H.<\/strong>, and Reed, F.A. (2018) Gene expression across tissues, sex, and life stages in the sea urchin Tripneustes gratilla<\/em>. Marine Genomics<\/em><\/p>\n

Pespeni, M.H.<\/strong>, Ladner, J.T. and A. P. Moczek. (2017) Signals of selection in conditionally expressed genes in the diversification of three horned beetle species. Journal of Evolutionary Biology, 30:9, 1644-1657.<\/p>\n

Evans, T. G. *, Pespeni, M.H. *<\/strong>, G. E. Hofmann, S. R. Palumbi, E. Sanford. (2017) Transcriptomic responses to seawater acidification among sea urchin populations inhabiting a natural pH mosaic. Molecular Ecology<\/em>, DOI: 10.1111\/mec.14038.\u00a0* Equal contribution.<\/p>\n

Lloyd, M.M.<\/u>(P)<\/sup>, Makukhov, A.<\/u>(G)<\/sup> and Pespeni, M.H.<\/strong> (2016) Loss of genetic diversity as a consequence of selection in response to high p<\/em>CO2<\/sub>. Evolutionary Applications<\/em>, 9:9, 1124-1132.<\/p>\n

De Wit, P.*, Pespeni, M.H.*<\/strong>, & Palumbi, S. R. (2015) SNP genotyping and population genomics from expressed sequences\u2013current advances and future possibilities. Molecular ecology<\/em>, 24(10), 2310-2323. \u00a0* Equal contribution.<\/p>\n

Evans, T. G., J. L. Padilla-Gami\u00f1o, M. W. Kelly, Pespeni, M.H.<\/strong>, F. Chan, B. A. Menge, B. Gaylord, T. M. Hill, A. D. Russell, S. R. Palumbi, E. Sanford, G. E. Hofmann. (2015) Ocean acidification research in the \u2018post-genomic\u2019 era: roadmaps from the purple sea urchin Strongylocentrotus purpuratus<\/em>. Comparative Biochemistry and Physiology, Part B.<\/em>, 185:33-42.<\/p>\n

Kijimoto, T., E.C. Snell-Rood, Pespeni, M.H<\/strong>., G. Rocha, K. Kafadar, A.P. Moczek. (2014) The nutritionally responsive transcriptome of the polyphenic beetle Onthophagus taurus<\/em> and the importance of sexual dimorphism and body region. Proceedings of the Royal Society, B<\/em>., 281:1797, 2014-2084.<\/p>\n

Moczek, A. P., T. Kijimoto, E. Snell-Rood, G. Rocha, M. H. Pespeni,<\/strong> K. Kafadar. (2014) Evolutionary and ecological genomics of developmental plasticity: novel approaches and first insights from the study of horned beetles. In: Ecological Genomics; edited by C. Landry and N. Aubin-Horth. Springer Verlag, Berlin, 127-148.<\/p>\n

Pespeni, M.H.<\/strong>, F. Chan, B. A. Menge, S. R. Palumbi. (2013) Signs of adaptation to local pH conditions across an environmental mosaic in the California Current Ecosystem. Integrative and Comparative Biology, <\/em>53:5, 857-870.<\/p>\n

Pespeni, M.H.<\/strong>, E. Sanford, B. Gaylord, T. M. Hill, J. D. Hosfelt, H. Jaris, M. LaVigne, E. Lenz, A. D. Russell, M. K. Young, and S. R. Palumbi. (2013) Evolutionary change during experimental ocean acidification. Proceedings of the National Academy of Sciences, <\/em>110:17, 6937-6942.<\/p>\n

[Press coverage by Nature, Scientific American, New Scientist, Mother Jones, Science News for Kids<\/em>, and more.]<\/p>\n

Pespeni, M.H.<\/strong> and S. R. Palumbi. (2013) Signals of selection in outlier loci in a widely dispersing species across an environmental mosaic. Molecular Ecology<\/em>, 22:13, 3580-3597.<\/p>\n

Pespeni, M.H.<\/strong>, B. Barney and S. R. Palumbi. (2013) Differences in the regulation of growth and biomineralization genes revealed through long-term common-garden acclimation and experimental genomics in the purple sea urchin. Evolution, <\/em>67:7, 1901-1914.<\/p>\n

Kijimoto, T.,* Pespeni, M.H.*<\/strong>, O. Beckers,* and A. P. Moczek. (2012) Beetle horns and horned beetles: emerging models in developmental evolution and ecology. WIREs Developmental Biology<\/em>, 2:3, 405-418. \u00a0* Equal contribution.<\/p>\n

De Wit, P.,* Pespeni, M.H.*<\/strong>, J. T. Ladner, D. J. Barshis, F. Seneca, H. Jaris, N. Overgaard Therkildsen, M. Morikawa, and S. R. Palumbi. (2012) The Simple Fool\u2019s Guide to population genomics: Gene expression and SNP data analysis in the age of high-throughput sequencing. Molecular Ecology Resources<\/em>, 12, 1058-1067. \u00a0* Equal contribution.<\/p>\n

Pespeni, M.H.<\/strong>, D. A. Garfield, M. K. Manier, and S. R. Palumbi. (2012) Genome-wide polymorphisms show unexpected targets of natural selection. Proceedings of the Royal Society, B<\/em>., 279:1732, 1412-1420.<\/p>\n

Pespeni, M.H.<\/strong>, T. A. Oliver, M. K. Manier, and S. R. Palumbi. (2010) Restriction Site Tiling Analysis: accurate discovery and quantitative genotyping of genome-wide polymorphisms using nucleotide arrays. Genome Biology<\/em>, 11:R44.<\/p>\n

Woodson, C. B., D. I. Eerkes-Medrano, A. Flores-Morales, M.M. Foley, S.K. Henkel, M. Hessing-Lewis, D. Jacinto, L. Needles, M.T. Nishizaki, J. O\u2019Leary, C.E. Ostrander, Pespeni, M.H.<\/strong>, K.B. Schwager, J.A. Tyburczy, K.A. Weersing, A.R. Kirincich, J.A. Barth, M.A. McManus, L. Washburn. (2007) Local diurnal upwelling driven by sea breezes in northern Monterey Bay. Continental Shelf Research<\/em>, 27:18, 2289-2302.<\/p>\n

Pespeni, M.H.<\/strong>, M. Hodnett, K. S. Abayasiriwardana, J. Roux, M. Howard, V. C. Broaddus and J.F. Pittet. (2007) Sensitization of mesothelioma cells to tumor necrosis factor\u2013related apoptosis\u2013inducing ligand\u2013induced apoptosis by heat stress via the inhibition of the 3-phosphoinositide-dependent kinase 1\/Akt pathway. Cancer Research<\/em>, 67, 2865-71.<\/p>\n

Godzich, M., M. Hodnett, J. A. Frank, G. Su, Pespeni, M.H.<\/strong>, A. Angel, M. B. Howard, M. A. Matthay and J. F. Pittet. (2006) Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats. The FASEB Journal<\/em>, 20, 1519-1521.<\/p>\n

Roux, J., H. Kawakatsu, B. Gartland, Pespeni, M.H.<\/strong>, D. Sheppard, M.A. Matthay, C. Canessa, J.F. Pittet. (2005) Interleukin-1a decreases expression of the epithelial sodium channel alphaENaC in lung epithelial cells via a p38 MAP kinase-dependent signaling pathway. Journal of Biological Chemistry<\/em>, 280, 18579-89.<\/p>\n

Pespeni, M.H.<\/strong>, R.C. Mackersie, H. Lee, D. Morabito, M. Hodnett, M. Howard, and J.F. Pittet. (2005) Serum levels of Hsp60 measured early after injury correlate with the development of acute lung injury following severe trauma. Journal of Surgical Research,<\/em> 126, 41-7.<\/p>\n

Pespeni, M.H.<\/strong>, M. Hodnett, and J.F. Pittet. (2005) In vivo stress preconditioning. Methods,<\/em> 35, 158-64.<\/p>\n

Pittet, J.F.,* H. Lee,* Pespeni, M.H.*<\/strong>, A. O\u2019Mahony, J. Roux, and W.J. Welch. (2004) Stress-induced inhibition of the NF-kB signaling pathway results from the insolubilization of the IkK complex following its dissociation from Hsp90. Journal of Immunology,<\/em> 174, 384-94. \u00a0* Equal contribution.<\/p>\n

Lee, H.,* Pespeni, M.H.,*<\/strong> J. Roux, P.A. Dennery, M.A. Matthay, and J.F. Pittet. (2004) HO-1 induction restores c-AMP-dependent lung epithelial fluid transport following severe hemorrhage in rats. The<\/em> FASEB Journal,<\/em> 19, 287-9. \u00a0* Equal contribution.<\/p>\n","protected":false},"excerpt":{"rendered":"

Please visit\u00a0Google scholar\u00a0and ResearchGate profiles for up-to-date publications. Please email mpespeni@uvm.edu for PDFs or find them on ResearchGate. Pespeni lab mentees are underlined with superscripts indicating career stage: postdoc(P), graduate student(G), undergraduate(U), research assistant(R). Preprints of papers in review! Petak, C.\u2020, Sadler, D.\u2020, Nunez, J.C.B.*, and Pespeni, M.H.* Inversion polymorphisms are maintained by balancing selection … Continue reading Publications<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":2319,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"open","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blog.uvm.edu\/mpespeni\/wp-json\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.uvm.edu\/mpespeni\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blog.uvm.edu\/mpespeni\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blog.uvm.edu\/mpespeni\/wp-json\/wp\/v2\/users\/2319"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.uvm.edu\/mpespeni\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":30,"href":"https:\/\/blog.uvm.edu\/mpespeni\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":749,"href":"https:\/\/blog.uvm.edu\/mpespeni\/wp-json\/wp\/v2\/pages\/2\/revisions\/749"}],"wp:attachment":[{"href":"https:\/\/blog.uvm.edu\/mpespeni\/wp-json\/wp\/v2\/media?parent=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}