Effect of nicotine, alcohol, and THC on vein diameter

Nicotine shown to have half the constrictive properties on veins as alcohol, and marijuana actually will make them bigger (with vasorelaxatory properties identified in THC)!

Nicotine and vein constriction:
“Smoking was associated with significant changes in the aortic pressure-diameter relation that denote deterioration of the elastic properties and were maintained during the whole study period: the slope of the pressure-diameter loop became steeper (baseline, 35.43±1.38; minute 1, 45.26±1.65; peak at minute 10, 46.36±1.69 mm Hg/mm; P<.001) and aortic distensibility decreased (baseline, 2.08±0.12; minute 1, 1.60±0.08; nadir at minute 5, 1.54±0.07×10−6 cm2·dyne−1P<.001). In contrast, no changes in aortic elasticity indexes were observed with sham smoking."

Alcohol and vein constriction:
“Blood ethanol levels achieved at 60, 120, and 180 minutes were 649+-48, 1,285±81, and 2,546+-130jug/ml, respectively. LAD cross-sectional area was reduced significantly from control at the end of each of the three dosing periods (-24± 5%, -40± 3%, and -53±.3%; p<0.004). a-Adrenergic blockade had no effecton LAD cross-sectional area, while nicardipine partially reversed the ethanol-induced vasoconstriction. No significant change in vessel cross-sectional area took place in control dogs."
Marijuana and vein relaxation:
“The present results provide strong evidence that THC is a PPARγ ligand, stimulation of which causes time-dependent vasorelaxation”
This results in a lower blood pressure and better athletic performance.
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